Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp221 | Cell biology: osteoclasts and bone resorption | ECTS2013

Modulation of osteoclastogenesis by antihypertensive drugs

Oliveira Teresa , Costa-Rodrigues Joao , Ferraz Ricardo , Prudencio Cristina , Fernandes Maria

Despite its rigid structure, bone is a dynamic tissue that is in constant remodeling. This process requires the action of the bone-resorbing osteoclasts and the bone-synthesing osteoblasts. One of the adverse effects attributed to some antihypertensive agents is the ability to alter normal bone metabolism. However, their effective actions on human bone cells remain to be clarified. In this work, the effects of five calcium channel blockers, a class of antihypertensive drugs (A...